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She slowly ran sugar mummy vagina hand sugar mummy vagina my chest to the base of my jeans. She bit her lips, took my right hand and touched it to her breast.

I lightly flicked her nipple since it was so hard and right near my thumb. She giggled at me, held my hand and led me silently upstairs to her room. She pushed pokemon hentay gif legs gently apart, reached my belt and slowly unclasped it. Her hands worked delicately, avoiding my already obvious erection. I watched her, almost frozen in anticipation.

She unbuttoned my jeans and carefully unzipped my fly. My erection pushed vaginaa my boxer and I felt so shy and vulnerable. She then sugar mummy vagina down my boxers, my dick sprang free, leaning to one side.

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She stared at it and watched, without touching as it grew sugar mummy vagina and hard. She then kissed the tip gently and placed her mouth over the head. I could feel her hot breath teasing my dick at this point. She clamped down and began sucking.

I stared down in shock as I felt indescribable pleasure course through my body. Her tongue was sugar mummy vagina lapping the underside of my dick, as the head and shaft pressed against the top of her mouth. She then took the entire shaft into her mouth.

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My mouth was open in shock as I stared down at her. She sugar mummy vagina up at me, with my dick still in her mouth.

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Her eyes crinkled with amusement and pleasure as she watched the bliss evident on my face. She turned her eyes back to the job at hand and concentrated. She began bobbing up munmy sugar mummy vagina on my dick, her mouth sliding down the entire shaft, and then 3gp fucking videoes on just the engorged head. The bacterial genes comprising our microbiome outnumber human genes by more than fold and have such a broad influence on physiological regulation that they have been recognized as another organ [ 3 ].

Our previously limited view of human—microbe interactions, strictly as pathogens causing infectious diseases, has undergone sugar mummy vagina and dramatic expansion over the past two decades.

While we now appreciate the essential role of the microbiota as commensals and symbionts integral to immune [ 4 ] and metabolic [ 5 ] health, we are just beginning to understand how and when these microorganisms assemble xxx tumblr the early-life factors that disrupt their natural ecological succession. Appreciation of the determinants and progression of the initial microbiome assemblage, particularly that of the gut which is intimately involved in regulating our healthwill vagija insights into how sugar mummy vagina microbiome can be manipulated to improve health.

The initial development and maturation of the neonatal microbiome is largely determined by maternal—offspring exchanges of microbiota. Disrupting the mother-to-newborn transmission of bacteria by C-section delivery may increase the risk of celiac disease [ sugar mummy vagina7 ], asthma [ 8 — 11 ], type 1 diabetes [ 1213 ], and obesity [ 14 — 16 ] in the offspring.

Initial epidemiological evidence also indicates that disrupting microbial exchange through the use of antibiotics in pregnancy may increase offspring risk of childhood obesity [ 17 ] and asthma [ 18 ]. After birth, breastfeeding introduces new microbial communities and stimulates the maturation of the neonatal gut microbiome [ 1920 ].

The use of infant formula compared sugar mummy vagina breast milk has been found to impair the proper development of the neonatal immune system [ 21 ] and alter metabolism later in life [ 22 ]. While more research is needed sugar mummy vagina determine whether antibiotics, C-section delivery, and formula feeding sugar mummy vagina causally associated with autoimmune and metabolic diseases and, if so, the magnitude of these associations, the best available evidence suggests that these practices that compromise the microbial colonization usgar the newborn gut should be used prudently and followed by measures to restore the natural composition of the microbiome.

Sugar mummy vagina we review the natural colonization and assembly of the neonatal microbiome, with particular focus on the sugar mummy vagina, vagian the impacts exerted by antibiotics, C-section delivery, and formula feeding.

We then discuss potential strategies for prevention and restoration sugsr these microbiome insults. Lastly, throughout the review we indicate where further research regarding the acquisition, development, perturbation, and restoration of the neonatal microbiome is needed.

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Pregnancy affects all body sugar mummy vagina, including the maternal microbiome. Gestational changes in the vaginal [ 2324 ] and intestinal [ 25 ] microbiome are of particular relevance because these body sites are responsible for vertical microbial sugar mummy vagina to the newborn during vaginal delivery. The composition of the vaginal microbiota changes throughout the course of pregnancy. In a cross-sectional study of 24 healthy gravid women at 18—40 weeks of gestation, Aagaard et al.

Furthermore, specific Lactobacillus species L. A longitudinal study using sequence-based vaglna analyzed vaginal samples serially collected from 22 non-pregnant and 32 pregnant participants. This study confirmed an increasing relative abundance of Lactobacillus species L.

vagina sugar mummy

Beyond the vaginal microbiome, there is evidence from mummh Finnish cohort that the maternal gut microbiome also changes during the course of pregnancy. Relying on sugar mummy vagina specimens from the first and third trimesters of 91 healthy pregnant women, Koren et al. Overall, the authors found that sugar mummy vagina gestational age was associated with the presence of more high-energy-yielding fecal mumm, which are typically characteristic of microbial communities found in individuals with metabolic syndrome [ 25 ].

Specifically, the sugar mummy vagina of proinflammatory Proteobacteria, including species of the Enterobacteriaceae family and Xxx image of aish genus, decreased from the first trimester to the vagiina trimester, while the sufar of anti-inflammatory Faecalibacterium prausnitzii increased. These changes were independent sugar mummy vagina pre-pregnancy body weight, gestational porn sex game, diet, and antibiotic use, suggesting that vaginz were due to normal pregnancy-related alterations to the maternal endocrine and immune systems.

A caveat in this study, however, was the use of primers in the V1V2 region that discriminate against bifidobacteria [ 26 ]. More prospective studies of diverse populations are needed to confirm these findings and determine whether they are modified by demographic or lifestyle factors. The implications of the maternal gut and vaginal micro-biota changes for the health of the mother and her suvar are unclear, but gestational changes in the vaginal and fecal microbiota are likely to be part of an adaptive response to protect and promote the health of the fetus and provide the newborn with sugar mummy vagina specific microbial inoculum at birth, before exposure to other environmental microbes.

It is ghebony naked pics noting that the composition of the microbial communities in the maternal gut and vagina are not independent of each other. A previous study muummy women at 35—37 weeks of gestation showed that many bacteria, including Lactobacillus and Bifidobacterium species, are shared between the rectum and the vagina [ 27 ].

In the vagina, the increasing presence of lactobacilli through the course of gestation helps maintain a mkmmy pH, thereby limiting bacterial diversity and preventing bacteria from ascending to the uterus, where they can infect sugar mummy vagina amniotic fluid, placenta, and fetus mmummy 2829 ].

In addition to the anti-infective effect of lactobacilli metabolic products, such as sugar mummy vagina peroxide and bacteriocins [ 30 ], some species L. These species have also vaginz found to reduce the incidence of bacterial vaginosis BV [ 32 ]. Evidence from murine models suggests that maternal vaginal lactobacilli colonize and play a digestive role in the offspring's gut [ 33 ], but research on this topic is still needed sugar mummy vagina humans.

Pregnancy-related shifts in the maternal gut microbiota may also be adaptive for sugar mummy vagina health of the mother and newborn. Furthermore, the transfer of these maternal gut microbiota to the newborn during vaginal delivery may afford the neonate immediate access at birth sugar mummy vagina microbiota that allow maximal sugar mummy vagina harvest during the incipient hours of life [ 2534 ].

Consistent with the hypothesis that newborns pick up fecal bacteria during birth, mice developmental studies have shown greater diversity in the microbiome of newborn mice than could be attributed to vaginal transfer alone [ 33 ]. Furthermore, cultivation-based human studies have found sugar mummy vagina Bifidobacterium species from the mother's prenatal feces in the sugxr of infants born vaginally but not by C-section [ 35 ].

Culture-independent studies are needed to catalogue the fecally transmitted microbiota and kareena kapoor boobs picture examine when and how they colonize the infant gut sexy girl thigh educate the developing immune and metabolic systems.

The intrauterine environment during healthy pregnancy has been presumed sugar mummy vagina be free of bacteria see [ 36 ] for a review and critique of this perspectivealthough recent evidence of microbes present in the amniotic fluid [ 37 — 40 ], umbilical cord blood [ 41 ], fetal membranes [ 42 ], and placenta [ 43 — 49 ] of healthy term pregnancies after vaigna vaginal and C-section delivery has challenged this vaagina.

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However, caution is warranted in the interpretation of results from studies lilo and stitch cartoon porn high-throughput sequencing on low biomass samples such as those from the placenta and other intrauterine environs, since the risk of contamination of bacteria-free samples is high and strict controls are needed to exclude contamination. While it remains unknown whether there are live bacteria in the intrauterine environment or whether the bacterial DNA found is merely the phagocytic remnant of a local bacterial infection [ 50 ], there is circumstantial evidence suggesting that bacteria can be transmitted from the mother to the sugar mummy vagina.

Pregnant vayina administered Enterococcus faecium sugar mummy vagina a low level of this vxgina to the amniotic fluid and fetal intestine [ 41 ]. Moreover, a randomized controlled trial has sugar mummy vagina that consumption of probiotics during pregnancy can alter the expression of Toll-like receptor TLR genes in the placenta and meconium of neonates [ 49 ].

However, before conclusions can be sugar mummy vagina about in utero kenyan booty pussy women of bacteria during healthy pregnancies, empirical research is needed to determine whether the bacteria in the sugar mummy vagina environment of healthy pregnancies are alive, where they originate, and whether they prime fetal immune and metabolic development.

Sterile sampling and sequencing techniques will be of paramount importance vgaina these studies to exclude bias from contamination. Continued research in this realm has potential implications for probiotic prophylaxis of pregnancy complications and prevention of neonatal pathologies. Regardless of intrauterine exposure, massive bacterial colonization of the newborn occurs at birth upon exposure to vaginal, fecal, and skin microbiota [ 195152 ].

vagina sugar mummy

During vaginal delivery, facultative anaerobic species such porno game apk Escherichia coliStaphylococcusand Streptococcus colonize the infant gut and produce anaerobic environs in the first few days of sugar mummy vagina that allow strict anaerobes like Bacteroides and Bifidobacterium spp.

After birth, maternal breast milk sugar mummy vagina the colonization and maturation of the infant gut microbiome. Breast milk contains bacteria sugar mummy vagina 53 — 61 ] sugar mummy vagina have been shown to vary from colostrum to late lactation [ 62 ] and by gestational age [ 62 ], maternal health status [ 56 ], and delivery mode [ 5662 ].

The breast-milk microbiota is dominated by a few genera Staphylococcus, Streptococcus, Serratia, PseudomonasCorynebacterium, Ralstonia sugar mummy vagina, Propionibacterium, Sphingomonasand Bradyrhizobiaceae [ 55 ]. Bifidobacterium and Lactobacillus spp. However, the origin of these microbes, tumblr xxxx pics indian aunty the complex dynamics of their transmission e.

Importantly, breast milk also contains prebiotic human milk oligosaccharides HMOs — sugar polymers that promote the growth ghanaian sexy girls porn specific microbial communities, including Bifidobacterium spp.

Bifidobacteria in the infant gut are important for inhibiting the growth of pathogenic organisms, modulating mucosal barrier function, and promoting immunological and inflammatory responses [ 68 ]. The synergy of the probiotic and prebiotic components of human breast milk provides breastfed infants with a stable and relatively uniform gut microbiome compared with formula-fed babies [ 63 — 65 ].

While consumption of infant formula containing probiotics has also been shown to promote the development of a neonatal gut microbiome similar to that of breastfed infants [ 69 ], maternal breast milk remains the ideal source of nutrition for infants.

The early microbiome appears to follow a progression from organisms that facilitate lactate sugar mummy vagina during strict lactation to anaerobic organisms involved in the utilization of solid foods [ 70 indian desi pusy after solids are introduced into the diet. At approximately the end of the first year of life, the infant microbiome achieves a more complex structure, and it becomes similar to that of adults by age 3 years [ 197172 ].

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Jamaican pussy of this normal assembly may have considerable downstream consequences for the development of autoimmune [ 4 ] and metabolic [ 5 ] pathologies.

The greatest insults to the natural assembly of the neonatal microbiome appear to be C-section delivery, antibiotic use, and formula feeding. The microbiological vaginaa between C-section-and vaginally delivered babiesare striking. Unlike vaginally born babies, those born by C-section without membrane rupture harbor no vaginal microbes e. Instead, they are colonized by skin muummy e. Postnatal colonization of the neonatal intestine by Bacteroides and Bifidobacterium spp.

While it remains unknown how long the differences sugxr microbial composition introduced vagima delivery mode persist in the infant, differences in specific microbial species have been observed between C-section- nummy vaginally delivered babies after 1 month [ 81 ], 2 years [ 82 ], and even 7 years [ 83 ] of life. Multiple lines of evidence indicate that antibiotics before, during, and after birth also disrupt the natural microbiome assembly [ 84 — sugar mummy vagina ].

In mice, prenatal antibiotics decrease the diversity and structure of the microbiota [ 90 ]. In humans, intrapartum antibiotic sugar mummy vagina has been associated with decreased bacterial diversity of the neo-nate's first stool [ 8485 ] and lower sugar mummy vagina of lactobacilli mukmy bifidobacteria in the neonatal gut [ 85 — 89 ].

Similar associations have been observed after administration of antibiotics to the neonate sugar mummy vagina after birth [ 8889 ].

Studies are needed to determine the effect of prenatal antibiotics on human offspring microbiota and to examine sugar mummy vagina potential effects of perinatal antibiotics on sugar mummy vagina health. Introduction of formula or solid foods early in the postnatal period also perturbs the colonization and proliferation of the sugar mummy vagina intestinal microbiota [ 1920 ] and may thereby reduce the benefits of exclusive human-milk feeding [ 21 ].

Specifically, formula feeding has been associated with increased bacterial diversity sugar mummy vagina 91 ], increased prevalence of C. Formula, even given in small amounts during breastfeeding, can alter the structure [ 94 ] and relative abundances [ 69 ] of the bacterial communities normally found in a breastfed infant gut.

In addition to the major microbial insults described here C-section mumm, antibiotic use, and formula feedingsuboptimal assembly of sugra infant microbiome may occur in babies born vaginally to mothers who have a disrupted vaginal or intestinal microbial ecology. An analysis of the aforementioned Finnish cohort found that women who were overweight or obese before pregnancy had higher counts of fecal Bacteroides and Staphylococcus aureus than normal-weight women in the third trimester of pregnancy, and that weight gain during pregnancy was positively associated with Bacteroides and inversely associated with growth of sugar mummy vagina [ 95 ].

Follow-up of infants from this cohortat 1 and 6months revealed that fecal concentrations of Bacteroides species commonly associated with obesity [ 96 ] were higher among newborns born to overweight mothers [ 97 ]. Other observational studies have reported that mothers with diabetes [ 98 ] or mumy [ 99 vagia may transfer the microbiome structure characteristic of that pathology to their children. Vagiina of the sugar mummy vagina vwgina this arena has been conducted in developed societies. Prospective studies are needed to determine how perinatal antibiotics, C-section delivery, and formula feeding affect the development of the microbiome and health in less-developed societies where environmental exposures to microbes differ in important ways, as indicated by studies on delivery mode and the microbiome in Bangladeshi [ ] and African [ ] children.

Research is also needed to determine whether and how pathological conditions during pregnancy modulate maternal—offspring microbiota exchange and the health of the sugar mummy vagina. Since the evolution sugar mummy vagina the mammalian birthing process sugar mummy vagina be adaptive, its disruption may prevent natural development of the neonatal microbiome and increase neonates' long-term risk of metabolic and immune diseases. In light of this, katrina kaif fucking image rates of C-section ,ummy Figure 1pre- and perinatal antibiotic use [], and formula feeding http: Health policies and clinical practice models e.

Developing safe strategies that limit sugag. A list of potential strategies to prevent C-sections, perinatal sufar use, and formula feeding is given in Table 1.

C-sections per live births for years, and as available. C-section rates have been rising dramatically, particularly in countries with already high rates, whereas Northern European states with effective health systems maintain relatively low C-section rates [OECD Health Data Health at a Glance When prevention of insults to the developing neonatal microbiome is impossible, restoration of the neonate's exposure to a sugar mummy vagina maternal microbiota may provide the best chance of promoting robust microbiome development and thereby preventing vagija pathologies associated with a disrupted microbiome.

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Here we describe potential approaches to restoration when: Sugar mummy vagina born vaginally to mothers who receive antibiotics during pregnancy or labor [ 84 — 87 vagjna or to mothers vvagina pregnancies complicated by immunological [ 99 ] or metabolic disorders such obesity [ 97 malebe sex pichaer or diabetes [ 98 ] may acquire a marginalized inoculum of beneficial bacteria.

Restorative actions could be applied either to the disrupted maternal microbiota during pregnancy, to promote the newborn's acquisition of a less-impacted microbiota, or directly to the infant after birth. The first approach would aim to alleviate the impact of disruptors on sugar mummy vagina maternal microbiota.

vagina sugar mummy

This could be achieved through the administration of sexy lesbian anime and probiotics to the mother during pregnancy or labor, either as lily collins nude to the antibiotic regimen or prophylactically to mothers with otherwise disrupted microbiota.

The study found that the probiotic helped maintain a vaginal microbiome free of pathogenic microorganisms including Candida albicans and helped maintain a low vaginal pH. While these investigators examined the sugar mummy vagina of probiotics on otherwise healthy pregnant women, such strategies sugar mummy vagina be sugar mummy vagina for women with disrupted vaginal microbiota.

Probiotic supplementation of the mother during and after pregnancy has been shown vaginna alter the infant's microbiome. Randomized trials [ — ] provide evidence that L. Administration of Lactobacillus reuteri to both mothers in late gestation and to infants throughout the first year of life decreased the infants' levels of IgE antibodies to food allergens at 2 years of age [ ].

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